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Naoki Ishiguro Selected Research

Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)

1/2020Pharmacokinetics and safety after once and twice a day doses of meclizine hydrochloride administered to children with achondroplasia.
1/2020Severe achondroplasia due to two de novo variants in the transmembrane domain of FGFR3 on the same allele: A case report.
12/2017Activated FGFR3 promotes bone formation via accelerating endochondral ossification in mouse model of distraction osteogenesis.
1/2017Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia.
1/2017Clinical dosage of meclozine promotes longitudinal bone growth, bone volume, and trabecular bone quality in transgenic mice with achondroplasia.
8/2016Low bone mineral density in achondroplasia and hypochondroplasia.
2/2015Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene.
1/2013Meclozine facilitates proliferation and differentiation of chondrocytes by attenuating abnormally activated FGFR3 signaling in achondroplasia.

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Naoki Ishiguro Research Topics

Disease

113Rheumatoid Arthritis
04/2022 - 06/2003
61Neoplasms (Cancer)
01/2021 - 07/2002
22Spinal Cord Diseases
01/2021 - 10/2004
20Osteoarthritis
05/2021 - 01/2004
18Pain (Aches)
01/2021 - 08/2004
17Spinal Cord Injuries (Spinal Cord Injury)
01/2020 - 09/2004
16Infections
02/2022 - 07/2005
14Neoplasm Metastasis (Metastasis)
07/2020 - 10/2005
14Wounds and Injuries (Trauma)
07/2020 - 01/2011
13Inflammation (Inflammations)
08/2021 - 08/2009
11Osteoporosis
08/2020 - 06/2005
11Aggressive Fibromatosis (Desmoid)
12/2019 - 07/2009
11Osteosarcoma (Osteogenic Sarcoma)
06/2014 - 07/2005
10Breast Neoplasms (Breast Cancer)
12/2020 - 08/2011
10Kyphosis
08/2020 - 12/2005
10Achondroplasia
01/2020 - 10/2004
9Congenital Abnormalities (Deformity)
08/2020 - 05/2008
9Necrosis
01/2016 - 08/2005
8Osteonecrosis (Kienbock's Disease)
04/2021 - 03/2008
7Hemorrhage
01/2021 - 08/2004
7Spinal Cord Compression
05/2017 - 12/2005
6Chondrosarcoma
01/2022 - 05/2012
6Hip Dislocation
01/2022 - 10/2006
6Osteophyte
11/2020 - 05/2007
6Paralysis (Palsy)
08/2020 - 09/2009
6Sarcoma (Soft Tissue Sarcoma)
04/2019 - 03/2008
6Arthritis (Polyarthritis)
01/2016 - 12/2006
5Motion Sickness (Airsickness)
12/2022 - 01/2013
5Parkinson Disease (Parkinson's Disease)
01/2021 - 04/2007
5Joint Diseases (Joint Disease)
01/2020 - 01/2004
5Osteolysis
12/2018 - 09/2003
5Scoliosis
10/2016 - 10/2005
5Musculoskeletal Diseases (Musculoskeletal Disease)
01/2014 - 07/2012
4Cysts
01/2021 - 11/2017
4Ependymoma
01/2021 - 03/2007
4Intervertebral Disc Displacement (Herniated Disc)
02/2020 - 07/2006
4Pneumonia (Pneumonitis)
07/2017 - 03/2012
4Pathologic Constriction (Stenosis)
01/2017 - 08/2012
4Developmental Dysplasia of the Hip
09/2013 - 09/2005
4Margins of Excision
04/2013 - 11/2010
3Heterotopic Ossification (Ectopic Ossification)
01/2021 - 01/2013

Drug/Important Bio-Agent (IBA)

35Methotrexate (Mexate)FDA LinkGeneric
02/2022 - 09/2009
24Pharmaceutical PreparationsIBA
12/2022 - 03/2009
20Hyaluronic Acid (Hyaluronan)IBA
01/2020 - 08/2003
18Proteins (Proteins, Gene)FDA Link
12/2020 - 07/2002
15tocilizumab (atlizumab)FDA Link
08/2021 - 01/2009
14Adalimumab (Humira)FDA Link
02/2022 - 08/2012
14Abatacept (Orencia)FDA Link
11/2020 - 09/2013
11CateninsIBA
01/2022 - 01/2014
11Biological ProductsIBA
06/2018 - 07/2009
10Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2021 - 05/2005
9Certolizumab PegolFDA Link
03/2020 - 07/2014
9Meloxicam (Mobic)FDA LinkGeneric
12/2019 - 03/2006
8Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA
01/2020 - 01/2013
8Etanercept (Enbrel)FDA Link
09/2014 - 05/2009
7C-Reactive ProteinIBA
08/2021 - 08/2009
7Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
08/2017 - 03/2006
6Meclizine (Meclozine)FDA LinkGeneric
12/2022 - 01/2013
6Antirheumatic Agents (DMARD)IBA
01/2021 - 09/2009
6iguratimodIBA
01/2021 - 05/2013
6Member 1 Subfamily B ATP Binding Cassette TransporterIBA
12/2020 - 01/2012
6DenosumabFDA Link
08/2020 - 06/2016
6Matrix Metalloproteinases (MMPs)IBA
01/2020 - 01/2004
6HymecromoneIBA
01/2020 - 01/2012
6Cyclooxygenase 2 (Cyclooxygenase-2)IBA
05/2014 - 01/2005
6Infliximab (Remicade)FDA Link
06/2012 - 01/2005
5Tumor Necrosis Factor InhibitorsIBA
10/2019 - 03/2015
5golimumabFDA Link
09/2018 - 06/2012
5Keratan SulfateIBA
04/2015 - 04/2010
4GLPG0634IBA
04/2022 - 01/2022
4Zonisamide (Zonegran)FDA LinkGeneric
01/2021 - 01/2015
4CytokinesIBA
12/2020 - 01/2004
4Peptides (Polypeptides)IBA
12/2020 - 01/2013
4Biomarkers (Surrogate Marker)IBA
01/2020 - 06/2003
4Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA
01/2019 - 02/2012
4Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
10/2016 - 07/2002
4Monoclonal AntibodiesIBA
06/2016 - 12/2010
4Messenger RNA (mRNA)IBA
01/2016 - 01/2004
4Collagen Type II (Type II Collagen)IBA
06/2013 - 07/2004
3GadoliniumIBA
01/2021 - 01/2018
3Metformin (Glucophage)FDA LinkGeneric
12/2020 - 09/2015

Therapy/Procedure

46Therapeutics
12/2020 - 01/2005
20Osteotomy
01/2022 - 01/2005
18Laminoplasty
01/2021 - 10/2004
17Hip Replacement Arthroplasty (Total Hip Replacement)
01/2022 - 09/2003
16Decompression
02/2020 - 08/2004
13Operative Surgical Procedures
01/2021 - 07/2006
12Laminectomy
03/2018 - 12/2005
9Drug Therapy (Chemotherapy)
07/2020 - 11/2008
9Conservative Treatment
01/2019 - 12/2005
8Activities of Daily Living (ADL)
01/2020 - 02/2005
7Radiotherapy
12/2016 - 07/2009
6Pedicle Screws
08/2020 - 05/2008
6Traction
05/2017 - 09/2005
5Operative Time
07/2020 - 08/2004
5Nursing Care
01/2014 - 07/2012
4Knee Replacement Arthroplasty (Total Knee Replacement)
11/2020 - 07/2010
4Biological Therapy
10/2019 - 06/2012
4Spinal Fusion (Spondylosyndesis)
12/2018 - 01/2013
3Arthroplasty
05/2021 - 06/2012